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. Author manuscript; available in PMC: 2019 Oct 12.
Published in final edited form as: Neurosci Lett. 2016 Aug 16;631:97–103. doi: 10.1016/j.neulet.2016.08.021

Fig. 1.

Fig. 1.

Intra-thalamus infusion of ZD7288 reduced nociceptive behavior in CCI rats. (A, B) CCI-induced mechanical allodynia and thermal hyperalgesia lasted for weeks in rats (sham vs CCI. *P < 0.05, n = 6). (C,E) Infusion of ZD7288 into the VPL nucleus contralateral to the CCI side attenuated mechanical allodynia for 90 min. (D,F) Infusion of ZD7288 into the VPL nucleus contralateral to the CCI side transiently reduced thermal hyperalgesia for at least 30 min. (baseline vs after ZD7288 injection * p < 0.05, n = 6–8).