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Intra-thalamus infusion of ZD7288 did not alter nociceptive threshold in sham rats. (A, B) Infusion of ZD7288 (5 μg) into the right side of the VPL nucleus did not change the hindpaw mechanical and thermal threshold of sham rats. (C,D) Schematic drawing of the injection site in the thalamus and a representative brain section showing ZD7288 or saline injection site.
