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. Author manuscript; available in PMC: 2019 Oct 12.
Published in final edited form as: Neurosci Lett. 2016 Aug 16;631:97–103. doi: 10.1016/j.neulet.2016.08.021

Fig. 4.

Fig. 4.

Intra-thalamus infusion of ZD7288 reduced nociceptive behavior in rats with CFA-induced inflammatory monoarthritis. (A, B) CFA injection into the ankle joint induced mechanical allodynia and thermal hyperalgesia lasting for weeks in rats (saline vs CFA. *P < 0.05, n = 6). (C,E) Infusion of ZD7288 into the VPL nucleus contralateral to the CFA injection side attenuated mechanical allodynia for up to 120 min. (D,F) At 15 min after infusion of ZD7288 into the VPL nucleus contralateral to the CFA side, thermal hyperalgesia was significantly attenuated (baseline vs after ZD7288 injection * p < 0.05, n = 6–8).