Table 1.
Modeling inputs, assumptions and ranges of TB outcome for health states
| Probability | Active Case Finding arm (lower and upper limit) | Passive Case Finding arm (lower and upper limit) | Reference |
|---|---|---|---|
| Probability of TB Presumptive | 0.022 (0.02–0.03) | 0.046 (0.04–0.06) | [17, 34] |
| Probability of TB Test | 0.61 (0.49–0.73) | 0.82 (0.66–0.98) | [17, 34] |
| Probability of Positive TB test | 0.08 (0.06–0.10) | 0.13 (0.10–0.16) | [17, 34] |
| Probability of starting TB treatment | 0.94 (0.75–1.13) | 0.94 (0.75–1.13) | [17, 34] |
| Transition Probabilities | |||
| Probability of Successful TB treatment | 0.77 (0.62–0.92) | 0.75 (0.60–0.90) | [17, 34] |
| Probability of Failing TB treatment | 0.02 (0.01–0.02) | 0.04 (0.03–0.05) | [17, 34] |
| Probability of default during TB treatment | 0.19 (0.15–0.23) | 0.20 (0.16–0.24) | [17, 34] |
| Probability of Death during TB treatment | 0.02 (0.01–0.02) | 0.01 (0.008–0.012) | [17, 34] |
| Probability of dying from natural causes | Life tables | Life tables | [26] |
| Probability of relapse after successful treatment | 0.03 (0.02–0.04) | 0.03 (0.02–0.04) | [28] |
| Probability of mortality if no TB treatment | 0.33 (0.26–040) | 0.33 (0.26–0.40) | [29] |
| Probability of spontaneous cure | 0.25 (0.20–0.30) | 0.25 (0.20–0.30) | [30] |
| Cost | |||
| Cost of no TB symptom at screening | $2.15 (1.72–2.58) | $4.24 (3.39–5.09) | Additional file 1: Table S1 |
| Cost if no TB test with positive symptom | $2.15 (1.72–2.58) | $4.24 (3.39–5.09) | Additional file 1: Table S1 |
| Cost of screening and negative sputum test | $7.15 (5.72–8.58) | $11.24 (8.99–13.49) | Additional file 1: Table S1 |
| Cost of screening and no treatment if smear positive | $82 (65.60–98.40) | $48 (38.40–57.60) | Additional file 1: Table S1 |
| Cost of screening, tests and successful TB treatment | $223 (178.40–267.60) | $171 (136.80–205.20) | Table 2 |
| Cost of screening, testing and TB treatment before loss to follow-up | $112 (89.60–134.40) | $86 (68.80–103.20) | Additional file 1: Table S1 (loss to follow up at 3 month of TX) |
| Cost of screening, testing and TB treatment before death from disease | $149 (119.20–178.80) | $114 (91.20–136.20) | Additional file 1: Table S1 (Death at 4 month of TX) |
| Disease weights (DWs) | |||
| DW for no TB treatment | 0.0.331 (0.26–0.40) | 0.0.331 (0.26–0.40) | [31] |
| DW of well state | 0 | 0 | |
| DW of death | 1 | 1 | |