Table 4.

Enriched Gene Ontology terms and KEGG pathway identified for proteins with reduced expression in C-AME (< 0.5-fold) compared to F-AME

	Enrichment scores	Biological pathways	Proteins (UniProt Accession no.)	p
(A) Enriched GO terms (DAVID)
1	15.19	GO:0098609~cell-cell adhesion	P07355, P62820, Q8WUF5, P61026, P31947, P06733, P04075, Q9H444, P43487, Q9C0C2, P30041, Q15056, P46109, P31949, Q15907, Q99497, Q9UJU6, O60437, P00338, Q92817, P31939, Q16643, P20810, Q9NYL9, P0DMV9, Q16658, P63244, Q14847, Q8NC51, Q14247	1.3E-12*
2	6.45	GO:0043488~regulation of mRNA stability	P27695, P25788, P25789, P25786, P0DMV9, P20618, P28070, O14818, Q92945, P60900, P49721, P04792, P49720, Q8NC51, P28066	2E-6*
3	6.45	GO:0051603~proteolysis involved in cellular protein catabolic process	P20618, P25788, P25789, P25786, P28070, O14818, P07858, P60900, P49721, P49720	1E-4*
3	4.23	GO:0006096~glycolytic process	P60174, P04406, P00558, P04075, P00338, P06733, P06744	0.026*
(B) KEGG pathways (DAVID)
1	6.45	hsa03050:Proteasome	P20618, P25788, P25789, P25786, P28070, O14818, P60900, P49721, P49720, P28066	3.6E-4*
2	4.23	hsa01130:Biosynthesis of antibiotics	P40925, P60174, P04406, P37837, P06733, P00338, P04075, Q03154, P06744, P31939, P11766, P54687, P29401, P14324, P00558, P14550, P21399	0.014*

GO = gene ontology, KEGG = kyoto encyclopedia of genes and genomes, F-AME = fresh human amnion extract, C-AME = cryopreserved human amnion extract, DAVID = database for annotation, visualization and integrated discovery

The biological events were ranked using enrichment scores. *Adjusted Benjamini p < 0.05 represents statistical significance