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. 2019 Nov;96(5):641–654. doi: 10.1124/mol.119.117069

Fig. 7.

Fig. 7.

Relative chlorzoxazone metabolism and APAP-elicited liver injury in cultured WT and gp78-KO mouse hepatocytes. (A) INH-pretreated hepatocytes (three individual cultures) from WT and gp78-KO mice were incubated on day 4 with chlorzoxazone for 3 hours and 6-hydroxychlorzoxazone assayed as detailed in Materials and Methods. Values (mean ± S.D.) of three individual cultures. Statistical significance determined by the Student’s t test, *P < 0.05 vs. WT. (B) WT and gp78-KO mouse hepatocyte cultures were INH-pretreated, and on day 4 incubated with APAP (1 or 5 mM) for 0–24 hours. Aliquots of media were taken at the time points indicated and assayed for ALT activity as detailed in Materials and Methods. Values (mean ± S.D.) of three individual cultures. Statistical significance determined by the Student’s t test, *P < 0.05 vs. WT, **P < 0.01 vs. WT.