Fig. 9.

Relative tamoxifen metabolism in cultured WT and gp78-KO mouse hepatocytes. WT and gp78-KO mouse hepatocyte cultures were DEX-pretreated and on day 4 incubated with tamoxifen (40 μM) for 0–8 hours. Aliquots of cell media were taken at the time points indicated and assayed as detailed in Materials and Methods. Values (mean ± S.D.) of three individual cultures. Statistical significance determined by Student’s t test, *P < 0.05 or **P < 0.01 vs. WT.