TABLE 2.

P-gp substrates tested in combination with elacridar and tariquidar

Compound	Mechanism of Action
Mithramycin A	Alcohol dehydrogenase inhibitor
Danusertib	Aurora-A/B/C kinase inhibitor
Tozasertib	Aurora-A/B/C kinase inhibitor
PHA-793887	CDK1,2,3,4,5 inhibitor
Romidepsin	Histone deacetylase (HDAC) inhibitor
JNK-IN-7	JNK inhibitor
PKI-587	mTOR inhibitor
CB 300919	NAMPT inhibitor
AST-487	RET kinase inhibitor
Sepantronium bromide	Survivin inhibitor
Docetaxel	Tubulin polymerization promoter
Paclitaxel	Tubulin polymerization promoter
Vinorelbine	Tubulin polymerization inhibitor
RO495	Tyk 2 inhibitor
RA-XII	N/A (Natural product)

CDK, cyclin-dependent kinase.