Figure 1.

Timeline for streptozotocin (STZ) injection, exosome transplantation and metabolic analyses.

Notes: (A) High-dose of STZ (200mg/kg, once) was administered in mice to build a diabetic model. Exosomes derived from MIN6 cells or PBS were transplanted in situ pancreas after non-fasting glucose levels reached 11.1mmol/l. Body weight and non-fasted blood glucose concentrations were monitored once every week. (B) Low dose of STZ (140mg/kg, once) was intraperitoneally administered in mice. An intraperitoneal glucose tolerance test (IPGTT) was performed on day 7, day 17 and day 35. Exosomes or PBS were transplanted in situ pancreas on day 10 and were given via tail vein injection on day 21.

Abbreviations: IPGTT, intraperitoneal glucose tolerance test; STZ, streptozotocin.