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. Author manuscript; available in PMC: 2020 Aug 22.
Published in final edited form as: J Med Chem. 2019 Aug 2;62(16):7575–7582. doi: 10.1021/acs.jmedchem.9b00871

Figure 4.

Figure 4.

CP-10 inhibited proliferation of cancer cells and induced degradation of amplified/mutated forms of CDK6. (A) A panel of different cancer cells were treated with CP-10/PD/CP-9/CP-23 for 84 h before cell viability measurement by CCK-8. Relative absorbance was plotted. Error bar, SD. (B) CP-10 induced robust degradation of WT, D163G and S178P forms of CDK6. WT, D163G and S178P forms of CDK6-FLAG were stably introduced into MCF-7 cells via lentivirus. Cells were then treated as indicated for 24h before harvest for immunoblotting. Data were representatives of independent replicate experiments for at least three times.