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. Author manuscript; available in PMC: 2020 Aug 22.
Published in final edited form as: J Med Chem. 2019 Aug 2;62(16):7575–7582. doi: 10.1021/acs.jmedchem.9b00871

Table 1.

Structures and DC50 values for PROTACs deriving from palbociclib and pomalidomide.

graphic file with name nihms-1048984-t0002.jpg
Compounds Linker R DC50/nM CDK6 DC50/nM CDK4
CP-10 graphic file with name nihms-1048984-t0003.jpg H 2.1 >100
CP-5 graphic file with name nihms-1048984-t0004.jpg H 1.1 >100
CP-6 graphic file with name nihms-1048984-t0005.jpg H 24.2 >100
CP-7 graphic file with name nihms-1048984-t0006.jpg H 14.3 >100
CP-8 graphic file with name nihms-1048984-t0007.jpg H 31.0 >100
CP-13 graphic file with name nihms-1048984-t0008.jpg H 5.3 >100
CP-14 graphic file with name nihms-1048984-t0009.jpg H 10.6 >100
CP-15 graphic file with name nihms-1048984-t0010.jpg H 1.6 >50
CP-16 graphic file with name nihms-1048984-t0011.jpg H 1.7 >50
CP-21 graphic file with name nihms-1048984-t0012.jpg H 81.6 >100
CP-22 graphic file with name nihms-1048984-t0013.jpg H 86 8 >100
CP-9 graphic file with name nihms-1048984-t0014.jpg CH2CH3 ND ND
CP-23 graphic file with name nihms-1048984-t0015.jpg CH2CH3 ND ND

Notes. ND indicates no degradation.