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. Author manuscript; available in PMC: 2020 Oct 12.
Published before final editing as: Ann Biomed Eng. 2019 Apr 12:10.1007/s10439-019-02264-7. doi: 10.1007/s10439-019-02264-7

Figure 6: Femur fractures in EP1 antagonist treated mice heal with increase mechanical strength:

Figure 6:

Biomechanical testing on day 21 after fracture. Mice were with either Vehicle or EP1 antagonist for 5 days, starting on post fracture day 1. The experiment is presented as fold differences between paired EP1 antagonist treated mice and Vehicle treated mice. Altogether an N=9 animals per group was examined in two separate experimental cohorts that were combined. Statistical analysis was performed using paired student t-test. (*)=p<0.05 vs. age-matched vehicle treated animals. The mean values of the biomechanical measurements for the combined groups was Torsional rigidity (Vehicle = 125.3 ± 52.92 [N.mm/(rad/mm)]; EP1 antagonist = 261.1 ± 63.7 [N.mm/(rad/mm)]); Maximum torque (Vehicle = 6.46 ± 1.98 (N.mm); EP1 antagonist = 10.62 ± 1.16 (N.mm)); Yield to torque (Vehicle = 5.17 ± 1.67 (N.mm); EP1 antagonist = 8.2 ± 0.8 (N.mm)); and Energy to maximum (Vehicle = 0.35 ± 0.068 (N.mm*(rad/mm) vehicle; EP1 Antagonist = 0.8 ± 0.19 [N.mm*(rad/mm)]).