Table 3.
Comparison of the serum concentrations of renal enzymes in various groups at the beginning and end of the study
| Kidney enzymes | Positive control | Negative control | Prevention phase | Treatment phase | |||
|---|---|---|---|---|---|---|---|
| Normal saline | Alcohol (6 mL/kg/day· BW) | Alcohol (6 mL/kg/day· BW) + HAECSP (167.5 mg/kg/day·BW) | Alcohol (6 mL/kg/day· BW) + HAECSP (335 mg/kg/day· BW) | Alcohol (6 mL/kg/day·BW)/HAECSP (167.5 mg/kg/day· BW) | Alcohol (6 mL/kg/day· BW)/HAECSP (335 mg/kg/day· BW) | ||
| Creatinine (mg/dL) | Before the intervention | 0.42±0.01 | 0.40±0.02 | 0.39±0.02 | 0.40±0.03 | 0.39±0.03 | 0.39±0.03 |
| After the intervention | 0.42±0.01 | 0.76±0.09 | 0.51±0.01 | 0.45± −0.02 | 0.68±0.04 | 0.66±0.03 | |
| P-value | 0.415 | 0.000*** | 0.001** | 0.053 | 0.000*** | 0.000*** | |
| BUN (mg/dL) | Before the intervention | 50.50±5.50 | 51.53±7.72 | 52.91±3.58 | 51.76±2.83 | 51.51±3.16 | 52.61±4.72 |
| After the intervention | 50.25±6.84 | 91.61±5.95 | 64.98±6.99 | 55.08±3.15 | 81.95±6.79 | 66.58±5.20 | |
| P-value | 0.521 | 0.000*** | 0.001** | 0.066 | 0.000*** | 0.000*** | |
Notes: Values are given as mean±SEM for six rats in each group. Significant values are shown in bold. **P<0.01, ***P<0.001.
Abbreviations: HAECSP, hydroalcoholic extract of Crocus sativus petals; BUN, blood urea nitrogen.