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. 2019 Oct 8;14:8161–8177. doi: 10.2147/IJN.S214224

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© 2019 Chen et al.

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Blood pharmacokinetics and tissue distribution of BSH and BSH-conjugated polymers. Boron concentrations (%ID/g of tissue) in (A) blood, (B) tumor, and (C) muscle tissue were evaluated on A549 subcutaneous tumor-bearing nude mice at 6, 12, and 24 hrs after intravenous administration of BSH or BSH-conjugated polymers (20 mg/kg on a boron basis). (D) Tumor to blood distribution ratio of boron after injection of BSH or BSH-conjugated polymers. (E) Tumor to muscle distribution ratio of boron after injection of BSH or BSH-conjugated polymers. The results are expressed as mean ± SD (n = 3). **P < 0.01, ***P < 0.001.