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. 2019 Oct 8;14:8161–8177. doi: 10.2147/IJN.S214224

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© 2019 Chen et al.

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The effect on the tumor following either PBS or Endostar administration in mice bearing B16F10 tumors. (A) Immunohistochemistry of tumor tissues. The vascular mimicries (top arrow) are PAS⁺ and show purple, while the endothelium-dependent vessels (bottom arrow) are CD34⁺ and show brown. Original magnification: 20X and 40X. (B) Immunofluorescence staining for CD34 and α-SMA in tumor tissues. The tumor tissues were also incubated with DAPI to show blue fluorescence. The degree of overlap of CD34 and α-SMA indicates vascular maturity. Scale bar = 50 μm. (C) Boron concentrations in tumor were evaluated at 24 hrs after intravenous administration of iRGD-PEG-PCCL-B (20 mg/kg on a boron basis). The data are expressed as mean ± SD (n = 3). ***P < 0.001.