Table 3.
Genotype Frequencies Of TYMS Polymorphisms In Cases And Controls
| Model | Genotype | Control (n, %) | Case (n, %) | OR (95% CI) | P-value* |
|---|---|---|---|---|---|
| rs1059394 HWE: P=0.53 | |||||
| Co-dominant | CC | 131(10.1%) | 80 (13.2%) | 1.00 (reference) | |
| Heterozygote | CT | 548(42.1%) | 255 (42.2%) | 0.76(0.56–1.04) | 0.09 |
| Homozygote | TT | 621(47.8%) | 270 (44.6%) | 0.71(0.52–0.97) | 0.03 |
| Dominant | CC | 131(10.1%) | 80 (13.2%) | 1.00 (reference) | |
| CT+TT | 1169(89.9%) | 525(86.8%) | 0.74(0.55–0.99) | 0.04 | |
| Recessive | CC+CT | 679(52.2%) | 335(55.4%) | 1.00 (reference) | |
| TT | 621(47.8%) | 270(44.6%) | 0.88(0.73–1.07) | 0.20 | |
| Overdominant | CC+TT | 752(51.9%) | 350(57.8%) | 1.00 (reference) | |
| CT | 548(42.1%) | 255(42.2%) | 1.00(0.82–1.22) | 1.00 | |
| Allele | C | 810(31.2%) | 415(34.5%) | 1.00 (reference) | |
| T | 1790(68.8%) | 795(65.5%) | 0.87(0.75–1.00) | 0.05 | |
| rs2847153ª HWE: P=0.47 | |||||
| Co-dominant | GG | 534(41.1%) | 223(36.9%) | 1.00 (reference) | |
| Heterozygote | GA | 589(45.3%) | 295(48.9%) | 1.20(0.97–1.48) | 0.09 |
| Homozygote | AA | 177(13.6%) | 86(14.2%) | 1.16(0.86–1.57) | 0.32 |
| Dominant | GG | 534(41.1%) | 223(36.9%) | 1.00 (reference) | |
| GA+AA | 766(58.9%) | 381(63.1%) | 1.19(0.98–1.45) | 0.09 | |
| Recessive | GG+GA | 1123(86.4%) | 518(85.8%) | 1.00 (reference) | |
| AA | 177(13.6%) | 86(14.2%) | 1.05(0.80–1.39) | 0.71 | |
| Overdominant | GG+AA | 711(44.7%) | 309(51.2%) | 1.00 (reference) | |
| GA | 589(45.3%) | 295(48.8%) | 1.15(0.95–1.39) | 0.15 | |
| Allele | G | 1657(63.7%) | 741(61.3%) | 1.00 (reference) | |
| A | 943(36.3%) | 467(38.7%) | 1.11(0.96–1.28) | 0.16 | |
Notes: *Univariate logistic regression analysis for the distributions of genotype and allele frequencies. Adjusted for age and sex. ªGenotype deletion: cases n=1. The Co-dominant, Dominant, Recessive, Overdominant, Allele represented five models.
Abbreviations: HWE, Hardy–Weinberg Equilibrium; OR, Odd Ratio; CI, Confidence Interval.