Figure 3.

Multidentritic sensory neurons mediate chemical behavioural nociception responses. (a) Cartoon depicting the morphology, behavioural function, and nociceptive modality of the different peripheral sensory neurons. (b–g) Behavioural response to noxious chemical stimulus (HCl 9%). (b) Silencing of all multidendritic sensory neurons, by blocking the synaptic output using tetanus neurotoxin. Silencing specific sensory neurons using tetanus neurotoxin in class I (c), class II (d), class III (e) and class IV (f). (g) Comparison of the degree of the silencing effect in the md sensory neurons (classes I–IV). The genotype colour-code used in (b) applies for (b–f). (b–f) n = 90 for each condition, data from three independent replicates of at least 30 larvae each. Error bars represent mean ± s.e. Log-rank (Mantel–Cox) test was used to determine statistical significance between different groups.