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. 2019 Oct 9;14:8073–8094. doi: 10.2147/IJN.S220740

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© 2019 Mondal et al.

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Biodistribution of drug/formulation data and, tumor and tumor-related data in experimental animals.

Notes: (A) Biodistribution and accumulation data of ^99mTc labeled drug/formulations in experimental mice (a) time-dependent biodistribution and accumulation of ^99mTc-DOX at 0.5 hrs (d) and at 4 hrs, (b) ^99mTc -DOX-NP at 0.5 hrs (e) and 4 hrs, and (c) ^99mTc -DOX-Ab-NP at 0.5 hrs and (f) 4 hrs, in xenograft mice-bearing breast tumor. (B) Changes in tumor volume, animal body weight, and excised tumors from the experimental mice along with the tumor growth-related representative visual image data. (a) Relative changes in tumor volume with time. Data showed mean tumor volume (mean ± SD, n=3) in different experimental and control mice. The value p<0.05 shows the level of statistical significance. Prefix of p (i.e., a–j), indicates as mentioned below: “a” indicates statistical level of significance when data were compared against normal saline treated (control) mice on day 10; “b” indicates statistical level of significance when data were compared against DOX-treated mice on day 10; “c” indicates statistical level of significance when data were compared against normal saline treated (control) mice on day 15; “d” indicates statistical level of significance when data were compared against DOX-treated mice on day 15; “e” indicates statistical level of significance when data were compared against normal saline treated (control) mice on day 20; “f” indicates statistical level of significance when data were compared against DOX-treated mice on day 20; “g” indicates statistical level of significance when data were compared against DOX-NP-treated mice on day 20; “h” indicates statistical level of significance when data were compared against normal saline treated (control) mice on day 25; “i” indicates statistical level of significance when data were compared against DOX-treated mice on day 25; “j” indicates statistical level of significance when data were compared against DOX-NP-treated mice on day 25. (b) Change of body weight of nude mice-bearing tumor. Data represent mean ± SD (n=3); data showed that there was no statistically significant variation between the groups of mice. (c) Tumors excised from the experimental mice after treatment with saline/DOX/DOX-NP/DOX-Ab-NP. (d) Images on day 25 of nude mice bearing SKBR-3 tumor after treatment with saline/DOX/DOX-NP/DOX-Ab-NP. Tumor areas have been marked with red circles in the figure.

Abbreviations: ^99mTc-DOX: radiolabeled free-doxorubicin, ^99mTc-DOX -NP: radiolabeled doxorubicin loaded nanoparticles, ^99mTc-DOX-Ab-NP: radiolabeled doxorubicin loaded antibody conjugated nanoparticles; DOX, doxorubicin; Ab, antibody; NP, nanoparticle.