Table 1.
Composition of various experimental nanoparticle formulations with their physicochemical characteristics
| Formulation | PLGA:Drug: DCM (Ratio by weight) | Sabilizer used | Average particle diameter (Z-average) (nm) | Polydispersity indexa | Zeta potential (mV) | %Drug loadinga | %Entrapment efficiencya |
|---|---|---|---|---|---|---|---|
| PVA | 40:4:1 | PVA (2.5% w/v) | 357 | 0.398±0.03 | −7.39±0.008 | 5±0.02 | 55%±0.3 |
| PVA+TWEEN | 40:4:1 | PVA (2.5% w/v) &Tween 80 (14% v/v) (F2) | 220 | 0.234±0.01 | −14.7±0.009 | 8.5±0.015 | 93.5%±0.21 |
| PVA+PLU-68 | 40:4:1 | PVA (2.5% w/v) & Pluronic-68 (0.5% w/v) | 449 | 0.041±0.018 | −12.2±0.01 | 7±0.12 | 77%±0.5 |
| PVA+PLU-127 | 40:4:1 | PVA (2.5% w/v) & Pluronic- 127 (0.5% w/v) | 466 | 0.419±0.022 | −13.7±0.011 | 6.9±0.03 | 75%±0.33 |
| PVA+TPGS | 40:4:1 | PVA (2.5% w/v) & TPGS (0.03%w/v) | 640 | 0.925±0.011 | −9.98±0.008 | 6.03±0.15 | 66%±0.83 |
| Antibody- conjugated formulation | 40:4:1 | PVA (2.5% w/v) &Tween 80 (14% v/v) | 241 | 0.230±0.009 | −2.93±0.013 | 8±0.01 | 88%±0.17 |
Note: aEach value represents mean ± SD (n=3).
Abbreviations: PLGA, poly (lactide-co-glycolide); DCM, dichloromethane; PVA, poly(vinyl alcohol); TWEEN, tween 80; PLU-68, pluronic F68; PLU-127, pluronic F127; TPGS, D -α-tocopherol polyethylene glycol succinate.