Table 2. Semi-quantitative analysis of CD68+, CD163+ and CD204+ cell counts and ratios in lung tissues obtained from the IPF, IPF-AE and NSIP patients.
| Variables | Control group | IPF group | IPF-AE group | NSIP group | P value | ||||
|---|---|---|---|---|---|---|---|---|---|
| IPF vs. control | IPF-AE vs. control | NSIP vs. control | IPF vs. IPF-AE | IPF vs. NSIP | |||||
| Number | 14 | 16 | 9 | 8 | |||||
| The number of cells (/HPFs) | |||||||||
| CD68+ cells | 2.1 (0.8–5.6) | 45.6 (35.0–66.3) | 76.2 (65.2–104.7) | 59.6 (39.1–77.4) | <0.0001* | <0.0001* | 0.0001* | 0.0085* | 0.312 |
| CD163+ cells | 1.3 (0.35–3.4) | 42.7 (35.0–53.6) | 109.0 (70.8–131.5) | 54.7 (46.1–64.8) | <0.0001* | <0.0001* | 0.0001* | 0.0004* | 0.047 |
| CD204+ cells | 0.55 (0.15–1.1) | 33.1 (22.1–44.9) | 50.0 (33.8–66.5) | 32.6 (26.8–43.0) | <0.0001* | <0.0001* | 0.0001* | 0.119 | 0.772 |
| The ratio of number of cells | |||||||||
| CD163+/CD68+ cells ratio | 0.50 (0.30–0.93) | 0.90 (0.78–1.1) | 1.3 (1.2–1.5) | 0.95 (0.78–1.2) | 0.0482 | 0.0003* | 0.0242 | 0.0008* | 0.759 |
| CD204+/CD68+ cells ratio | 0.23 (0.075–0.37) | 0.68 (0.53–0.74) | 0.55 (0.42–0.75) | 0.60 (0.49–0.83) | 0.0006* | 0.0087* | 0.0056* | 0.179 | 0.477 |
Data were expressed as the median [25th to 75th percentiles of the interquartile range (IQR)]. HPFs; high power fields. *, P<0.05. The significant level was adjusted by Bonferroni’s correction. IPF, idiopathic pulmonary fibrosis; AE, acute exacerbation; NSIP, nonspecific interstitial pneumonia.