Figure 6.

In vivo elimination and suppression of teratoma formation via ADCC. Single‐cell suspension of hESCs was pretreated with ch2448 in vitro and injected into the right hind leg muscles of SCID mice (n = 3). Killing via ADCC relied on the capacity of ch2448 to interact with the Fc receptors on the mouse effector cells in vivo. (a) Buffer control (b) hESC pretreated with ch2448. ADCC, antibody‐dependent cell‐mediated cytotoxicity; hESC, human embryonic stem cell; SCID, male severe combined immunodeficient