. 2019 Aug 13;25(54):12452–12463. doi: 10.1002/chem.201900562

Table 2.

Properties of chemo‐optogenetic dimerization systems.

System	λ [nm]		Timescale	Ref.
	Association	Dissociation
pRap	365		dimerization: 1–2 min	32
FRB‐iFKBP	365		dissociation: no	32
cRb	365		dimerization: <1 min	34
FRB‐FKBP12	365		dissociation: no	34
dRap	365		dimerization: 3 min	33
FRB‐FKBP12	365		dissociation: no	33
ABA‐DMNB/DEACM	365/405	washout	dimerization: min	35
PYL‐ABI	365/405	washout	dissociation: 30 min	35
pcGA₃	377–470		dimerization: 3–10 s	36
GID‐GAI	(two‐photon uncaging at 800 nm)		dissociation: no	36
NTH/CTH	385–405 (NTH)	TMP addition	dimerization: t _1/2=15 s	37b, 37d
eDHFR‐HaloTag	385/444 (CTH)	TMP addition	dissociation: 2–10 min	37b, 37d
Nvoc‐TMP‐CI	405	TMP addition	dimerization: t _1/2=0.78 s	37c
eDHFR‐HaloTag	405	TMP addition	dissociation: 2 min	37c
MeNV‐HaXS	dimerizer addition	355	dimerization: min	38
SNAPTag‐HaloTag	dimerizer addition	355	dissociation: s	38
TNH	dimerizer addition	405	dimerization: t _1/2=2–5 min	37d
eDHFR‐HaloTag	dimerizer addition	405	dissociation: s	37d
CONC	405/458	405	dimerization: t _1/2=0.51 s	39
eDHFR‐HaloTag	405/458	405	dissociation: t _1/2=0.15 s	39