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. 2019 Oct 2;286(1912):20190716. doi: 10.1098/rspb.2019.0716

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© 2019 The Author(s)

Published by the Royal Society. All rights reserved.

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Figure 3. — Genes containing behaviour-associated SNPs are highly expressed in the brain and associated with gene ontology terms relating to brain development and function. (a) Enrichment tests using dog gene expression to identify tissue-specific genes. (b) Enrichment tests using human gene expression to identify tissue-specific genes. Bars reflect the −log10 (p-value) from a hypergeometric test for tissue-specific gene enrichment. The dashed line indicates −log10 (p = 0.05) and the results for brain tissue are highlighted in red. (c) Network plot for a subset of gene ontology terms relating to brain development and function that were associated with breed differences in behaviour. Edge colours and line widths reflect Resnik's similarity scores between GO terms, as implemented in NaviGO [59]. Wider and redder lines reflect greater similarity between nodes. Node sizes are inversely proportional to p-values from enrichment tests. (Online version in colour).