Table 1.
Clinicopathological characteristics of patients in the development and validation sets
| Characteristic | Development set |
Validation set |
p-valuea) | ||||
|---|---|---|---|---|---|---|---|
| Total (n=833) | LNM (–) (n=736) | LNM (+) (n=97) | Total (n=722) | LNM (–) (n=673) | LNM (+) (n=49) | ||
| Age (yr) | 61.8±10.6 | 61.9±10.6 | 60.4±10.7 | 67.8±10.6 | 67.9±10.5 | 67.0±11.0 | < 0.001 |
| Sex | |||||||
| Male | 518 (62.2) | 457 (88.2) | 61 (11.8) | 451 (62.5) | 425 (94.2) | 26 (5.8) | 0.909 |
| Female | 315 (37.8) | 279 (88.6) | 36 (11.4) | 271 (37.5) | 248 (91.5) | 23 (8.5) | |
| Tumor location | |||||||
| Colon | 536 (64.4) | 466 (86.9) | 70 (13.1) | 481 (66.6) | 449 (93.4) | 32 (6.7) | 0.347 |
| Rectum | 297 (35.7) | 270 (90.9) | 27 (9.1) | 241 (33.4) | 224 (93.0) | 17 (7.1) | |
| Endoscopic type | |||||||
| Polypoid | 659 (79.1) | 587 (89.1) | 72 (10.9) | 611 (84.6) | 567 (92.8) | 44 (7.2) | 0.005 |
| Non-polypoid | 174 (20.9) | 149 (85.6) | 25 (14.4) | 111 (15.4) | 106 (95.5) | 5 (4.5) | |
| Treatment | |||||||
| Endoscopic | 154 (18.5) | 154 (100) | 0 | 249 (34.5) | 249 (100) | 0 | < 0.001 |
| Surgery | 288 (34.6) | 248 (86.1) | 40 (13.9) | 209 (29.0) | 185 (88.5) | 24 (11.5) | |
| Endoscopic+surgery | 391 (46.9) | 334 (85.4) | 57 (14.6) | 264 (36.6) | 239 (90.5) | 25 (9.5) | |
| Histologic grade | |||||||
| Low | 813 (97.6) | 727 (89.4) | 86 (10.6) | 696 (96.4) | 648 (93.1) | 48 (6.9) | 0.164 |
| High | 20 (2.4) | 9 (45.0) | 11 (55.0) | 26 (3.6) | 25 (96.2) | 1 (3.9) | |
| Pathologic tumor size (mm) | 14 (10-20) | 15 (10-20) | 13 (10-20) | 19 (14-27) | 20 (14-27) | 17 (15-25) | < 0.001 |
| Depth of submucosal invasion | |||||||
| sm1 | 292 (35.1) | 276 (94.5) | 16 (5.5) | 318 (44.0) | 313 (98.4) | 5 (1.6) | 0.001 |
| sm2 | 260 (31.2) | 230 (88.5) | 30 (11.5) | 179 (24.8) | 163 (91.1) | 16 (8.9) | |
| sm3 | 281 (33.7) | 230 (81.9) | 51 (18.2) | 225 (31.2) | 197 (87.6) | 28 (12.4) | |
| Background adenoma | |||||||
| No | 248 (29.8) | 207 (83.5) | 41 (16.5) | 197 (27.3) | 178 (90.4) | 19 (9.6) | 0.279 |
| Yes | 585 (70.2) | 529 (90.4) | 56 (9.6) | 525 (72.7) | 495 (94.3) | 30 (5.7) | |
| Vascular invasion | |||||||
| No | 466 (55.9) | 453 (97.2) | 13 (2.8) | 604 (83.7) | 580 (96.0) | 24 (4.0) | < 0.001 |
| Yes | 367 (44.1) | 283 (77.1) | 84 (22.9) | 118 (16.3) | 93 (78.8) | 25 (21.2) | |
| Tumor budding | |||||||
| No | 673 (80.8) | 609 (90.5) | 64 (9.5) | 584 (80.9) | 551 (94.4) | 33 (5.7) | 0.963 |
| Yes | 160 (19.2) | 127 (79.4) | 33 (20.6) | 138 (19.1) | 122 (88.4) | 16 (11.6) | |
Values are presented as mean±SD, number (%), or median (IQR). LNM, lymph node metastasis; SD, standard deviation; IQR, interquartile range.
a)
p-value was calculated to test for difference between development and validation set.