. 2019 Apr 19;51(4):1639–1652. doi: 10.4143/crt.2019.023

Table 5.

Univariable and multivariable analysis of prognostic factor for disease-free survival

	Univariable analysis			AJCC 7th multivariable analysis			AJCC 8th multivariable analysis
	HR	p-value		HR	95% CI	p-value	HR	95% CI	p-value
Sex
Male	1			1			1
Female	0.541	0.020		0.850	0.474-1.522	0.584	0.854	0.478-1.524	0.592
Resection margin status
R0	1			1			1
R1/R2	4.223	0.001		1.299	0.444-3.798	0.633	1.223	0.421-3.551	0.712
Lymphovascular invasion
No	1			1			1
Yes	6.951	< 0.001		2.885	1.494-5.571	0.002	2.885	1.494-5.571	0.002
Perineural invasion
No	1			1			1
Yes	5.940	0.004		2.474	1.352-4.527	0.003	2.474	1.352-4.527	0.003
Grade (ENETS/WHO 2010)
G1	1			1			1
G2	8.403	< 0.001		5.026	2.516-10.043	< 0.001	5.026	2.516-10.043	< 0.001
AJCC 7th stage		< 0.001				0.965
I	1			1
II	4.616	< 0.001^a)	0.312^b)	0.855	0.376-1.944	0.709
III	8.539	0.004^a)	0.354^b)	1.058	0.202-5.538	0.947
IV	13.872	< 0.001^a)	0.521^b)	0.761	0.200-2.898	0.688
AJCC 8th stage		< 0.001							0.633
I	1						1
II	3.808	0.007^a)	0.006^b)				1.717	0.628-4.693	0.292
III	13.928	< 0.001^a)	< 0.001^b)				2.058	0.680-6.227	0.201
IV	30.618	< 0.001^a)	0.024^b)				2.158	0.541-8.613	0.276

AJCC, American Joint Committee on Cancer; HR, hazard ratio; CI, confidence interval; ENETS, European Neuroendocrine Tumors Society; WHO, World Health Organization.

^a)

p-values with stage I as the reference,

^b)

p-values with the previous stage as the reference.