. 2019 Apr 19;51(4):1639–1652. doi: 10.4143/crt.2019.023

Table 6.

Univariable and multivariable analysis of prognostic risk factor for overall survival rate

	Univariable analysis			AJCC 7th multivariable analysis			AJCC 8th multivariable analysis
	HR	p-value		HR	95% CI	p-value	HR	95% CI	p-value
Age (continuous)	1.033	0.078		4.053	1.826-8.998	0.001	1.069	1.028-1.111	0.001
Resection margin status
R0	1			1			1
R1/R2	4.246	0.004		2.228	0.457-10.875	0.322	1.855	0.404-8.517	0.427
Lymphovascular invasion
No	1			1			1
Yes	3.058	0.007		2.235	0.842-5.934	0.106	2.795	1.128-6.925	0.026
Perineural invasion
No	1			1			1
Yes	3.757	0.008		1.549	0.555-4.329	0.404	1.779	0.696-4.549	0.229
Grade (ENETS/WHO 2010)
G1	1			1			1
G2	2.478	0.021		1.250	0.486-3.127	0.644	1.559	0.631-3.852	0.336
AJCC 7th stage		0.001				0.387
I	1			1
II	2.734	0.002^a)	0.001^b)	2.440	0.848-7.016	0.098
III	3.445	0.230^a)	0.792^b)	1.362	0.135-13.713	0.793
IV	5.922	< 0.001^a)	0.763^b)	1.757	0.234-13.176	0.584
AJCC 8th stage		0.001							0.098
I	1						1
II	2.268	0.085^a)	0.077^b)				4.357	0.981-19.355	0.053
III	4.459	0.003^a)	0.077^b)				5.310	1.001-28.154	0.050
IV	9.802	< 0.001^a)	0.190^b)				6.509	0.808-52.472	0.079

AJCC, American Joint Committee on Cancer; HR, hazard ratio; CI, confidence interval; ENETS, European Neuroendocrine Tumors Society; WHO, World Health Organization.

^a)

p-values with stage I as the reference,

^b)

p-values with the previous stage as the reference.