Table 2.
Univariate and multivariate analyses for DFS and OS
| Variable | DFS |
OS |
||||||
|---|---|---|---|---|---|---|---|---|
| 5-Year rate | p-value (univariate) | HR (95% CI) | p-value (multivariate) | 5-Year rate | p-value (univariate) | HR (95% CI) | p-value (multivariate) | |
| Age (yr) | ||||||||
| < 40 | 50.9 | 0.089 | 74.7 | 0.290 | ||||
| ≥ 40 | 60.3 | 75.3 | ||||||
| ypT category | ||||||||
| 0-1 | 64.1 | 0.002 | 1 | 0.543 | 80.1 | 0.004 | 1 | 0.065 |
| 2-4 | 50.0 | 1.126 (0.768-1.652) | 68.9 | 1.534 (0.974-2.414) | ||||
| Nodal involvement | ||||||||
| Both SCL/IMN | 47.8 | 0.046 | 1.568 (1.066-2.304) | 0.022 | 63.4 | 0.019 | 1.818 (1.145-2.887) | 0.011 |
| Others | 60.3 | 1 | 78.0 | 1 | ||||
| No. of axillary lymph nodes | ||||||||
| 0-3 | 72.1 | < 0.001 | 1 | 0.001 | 80.5 | 0.001 | 1 | 0.354 |
| ≥ 4 | 49.1 | 1.950 (1.323-2.875) | 68.0 | 1.235 (0.791-1.928) | ||||
| Histologic grade | ||||||||
| 1 or 2 | 61.8 | 0.007 | 1 | 0.081 | 81.4 | 0.001 | 1 | 0.025 |
| 3 | 50.0 | 1.362 (0.963-1.928) | 64.8 | 1.647 (1.065-2.548) | ||||
| Lymphovascular invasion | ||||||||
| Absent | 64.0 | < 0.001 | 1 | 0.108 | 73.7 | 0.570 | ||
| Present | 49.1 | 1.363 (0.934-1.989) | 76.5 | |||||
| Molecular subtype | ||||||||
| Triple-negative | 39.0 | < 0.001 | 2.626 (1.482-4.653) | 0.001 | 58.6 | < 0.001 | 3.311 (2.121-5.170) | < 0.001 |
| Others | 63.9 | 1 | 80.8 | 1 | ||||
| Breast surgery | ||||||||
| BCS | 71.7 | < 0.001 | 1 | 0.004 | 85.4 | 0.001 | 1 | 0.002 |
| Mastectomy | 49.8 | 1.911 (1.224-2.984) | 69.2 | 2.421 (1.393-4.207) | ||||
| Postoperative chemotherapy | ||||||||
| No | 57.6 | 0.802 | 73.7 | 0.189 | ||||
| Yes | 57.7 | 77.0 | ||||||
| Hormonal therapy | ||||||||
| No | 49.2 | < 0.001 | 1 | 0.620 | 65.8 | < 0.001 | 1 | 0.350 |
| Yes | 65.1 | 0.884 (0.542-1.441) | 83.0 | 0.760 (0.427-1.352) | ||||
| Herceptin | ||||||||
| No | 54.2 | 0.042 | 1 | 0.867 | 72.3 | 0.032 | 1 | 0.270 |
| Yes | 65.5 | 0.960 (0.595-1.549) | 81.0 | 0.687 (0.352-1.338) | ||||
DFS, disease-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; SCL, supraclavicular lymph node; IMN, internal mammary lymph node; BCS, breast-conserving surgery.