Table 2.
No. | Combination therapy | Pasireotide-LAR first evaluation | Pasireotide-LAR last evaluation | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
FBG (g/L) | HbA1c (%) | Glucose tolerance | Treatment | FBG (g/L) | HbA1c (%) | Glucose tolerance | Treatment modifications | FBG (g/L) | HbA1c (%) | Treatment modification | |
1 | 0.99 | 5.6 | NGT | 1.15 | 5.9 | PD | 6.1 | ||||
2 | 1.19 | 7.2 | TD | Met + dpp4 | 1.08 | 8.4 | TD | insulin 4/d | Stop Pasireotide-LAR | ||
3 | 0.97 | 5.8 | PD | 1.08 | 6.5 | D | Stop Pasireotide-LAR | ||||
4 | 0.99 | 5.3 | NGT | 0.94 | 5.4 | NGT | 0.94 | 5.4 | |||
5 | 0.97 | 6.7 | D | 1.20 | 6.2 | PD | 1.01 | 6.3 | |||
6 | 1.03 | 5.8 | PD | 1.40 | 6.6 | TD | Dpp4 | 1.80 | 7.2 | ||
7 | 0.99 | 5.8 | PD | 1.21 | 6.5 | TD | Metf + dpp4 | 1.66 | 6.2 | ||
8 | 1.15 | 5.6 | PD | 1.20 | 6.2 | PD | 1.24 | 6.1 | |||
9 | 1.78 | 6.9 | TD | Insulin 3/d | 0.82 | 7.4 | TD | Dose increase | 10.9 | Stop Pasireotide-LAR | |
10 | 1.4 | 6.5 | TD | Met | NA | 7.6 | TD | + Dpp4 - sulf | 2.30 | 8.6 | Stop Pasireotide-LAR |
11 | 0.94 | 5.6 | NGT | 1.13 | 5.9 | PD | 6.1 | ||||
12 | 0.90 | 5.4 | NGT | 1.03 | 5.9 | PD | 0.99 | 5.8 | |||
13 | 1.01 | 5.5 | PD | 1.17 | 6.0 | PD | Stop Pasireotide-LAR | ||||
14 | 1.42 | 5.4 | TD | Insulin 4/d | 1.55 | 7.1 | TD | + Met | 2.34 | 8.4 | Stop Pasireotide-LAR |
15 | 1.06 | 6.3 | PD | 1.60 | 6.3 | D | Stop Pasireotide-LAR |
D, diabetes not treated with a specific medication; Dpp4, dpp4 inhibitor; DT, diabetes treated with medication; Met, metformin; NA, not available; NGT, normal glucose tolerance; PD, prediabetes.