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. 2019 Sep 9;8(10):1330–1353. doi: 10.1530/EC-19-0341

Table 2.

Review of published literature on head and neck TIO cases: list of index cases with relevant data.

Case no. Author Age/sex Location of tumor
Duration of symptoms Localizing imaging FGF-23 Persistence/recurrence
Secondary modality HPR
Pre-surgery Post-surgery
1 Renton (5) 53 F Left ethmoid 60 X-ray NA NA NA Hemangiopericytoma
2 Sweet (6) 25 F Left middle turbinate 12 CT NA NA No Hemangiopericytoma
3 Nitzan (7) 26 M Left mandibular molar legion 24 X-ray NA NA No Giant cell tumor
4 Nomura (8) 29 M Mandible 24 X-ray NA NA Persistence RT, chemotherapy, 2nd surgery, chemotherapy PMT ossifying fibroma like
5 Linsey (9) 54 F Right nasopharynx 30 CT NA NA NA PMTMCT
6 Shenker (10) 55 M Neck NA NA NA NA No PMTMCT
7 Sheshadri (11) 40 F Ethmoid sinus NA CT NA NA NA Hemangiopericytoma
8 Jefferies (12) 27 F Left maxillary sinus 24 CT NA NA NA PMT
9 Weidner (13) 39 F Right maxillary sinus 24 CT NA NA Recurrence Repeat surgery
Primitive mesenchymal tumor
10 Papotti (10) 38 F Nasal cavity NA NA NA NA No PMTMCT
11 Harvey (10) 32 F Thyroid 144 PE NA NA Persistence Repeat surgery: partial f/b total laryngectomy f/b RT and continued on medical management Malignant PMTMCT
12 Lee (14) 66 F Left nasal cavity 36 CT NA NA No Hemangiopericytoma
13 Catalano (15) 66 F Right maxillary and ethmoidal sinus many years CT NA NA No Hemangiopericytoma
14 Wilkins (16) 55 M Left infratemporal mass 24 CT NA NA No Sinonasal hemangiopericytoma like
15 David (17) 60 F Right subfrontal mass 18 CT NA NA Recurrence Medical management Hemangiopericytoma
16 Kim (18) 41 M Right upper premolar 48 PE NA NA No Giant cell tumor
17 Kim (18) 32 F Left mandibular molar area 96 PE NA NA No Ossifying fibroma
18 Avila (19) 48 M Mandible 60 MRI NA NA No Chronic inflammatory tissue with fibrosis and epithelial rests
19 Yang (20) 31 F Left mandible 96 CT NA NA NA PMT-MCT
20 Gonzalez-Compta (21) 69 F Right ethmoido-frontal mass 216 CT NA NA Patient died of tumor PMT
21 Ohashi (22) 43 M Left maxillary sinus 14 CT NA NA NA Hemangiopericytoma
22 Clunie (23) 60 F Ethmoid sinuses 60 CT NA NA Recurrence Medical management Hemangiopericytoma
23 Sandhu (24) 46 M Right ethmoid sinus 18 CT NA NA No Hemangiopericytoma
24 Reyes-Mugica (25) 9 F Left mandible 1.5 MRI NA NA No PMT-MCT
26 John (27) 54 F Right frontal, ethmoidal, sphenoid sinuses NA PE NA NA NA Patient received Immediate RT following surgery Malignant Schwannoma
27 Reis-Filho (28) 47 F Cavernous sinus 84 CT NA NA No PMTMCT
28 Fuentealba (29) 63 F Maxillary sinus 60 CT NA NA Persistence Surgery, RT, embolization Hemangiopericytoma
29 Ungari (30) 24 M Ethmoid NA CT NA NA NA Hemangiopericytoma
30 Folpe (10) 29 M Ethmoid/
sphenoid sinus
24 NA NA NA No Hemangiopericytoma
31 Folpe (10) 46 M Ethmoid sinus 36 NA NA NA Recurrence Repeat surgery Hemangiopericytoma
32 Dupond (31) 71 M Lower mandible 12 FDG-PET 199 Ru/mL (N <100) 22 Ru/mL (POD 8) NA PMTMCT
33 Kaylie (32) 46 F Temporal bone 120 CT NA NA NA PMTMCT
34 Inokuchi (33) 24 F Right nasal cavity and paranasal sinuses 4 CT 484 Ru/mL (N: 32–84) 58 Ru/mL (POD 3) No Hemangiopericytoma
35 Yoshioka (34) 45 M Clivus 10 MRI NA 49 pg/mL Recurrence After first surgery received RT followed by medical management. Octreotide was not effective. Hemangiopericytoma
36 Koriyama (35) 41 F Right maxillary sinus 36 CT 309 pg/mL (N: 10–50) 50 (2 h post surgery) No PMTMCT
37 Elston (36) 69 F Skull 84 Octreoscan 67 RU/mL (N: 3–45) 32 RU/mL (3–45) (POD 0) No PMTMCT
38 Beech (37) 42 M Right ethmoid sinus 84 MRI NA NA No Hemangiopericytoma
39 Ahn (38) 61 M Left lower buccal vestibule 17 PE NA NA No Hemangiopericytoma
40 Uramoto (39) 48 M Tongue 24 CT NA NA Recurrence Second surgery, RT
Malignant PMTMCT
41 Lewiecki (40) 46 M Mandible 24 Octreoscan 262 RU/mL (N <180) UD (POD 10) No PMT
42 Kenealy (41) 79 F Left ethmoid sinus NA CT 355 U/mL (N: 3–45) NA NA PMTMCT
43 Kenealy (41) 40 F Left ethmoid sinus 60 Octreoscan 484 U/mL (N: 3–45) NA NA Hemangiopericytoma
44 Kyoung-In Yun (42) 71 F Mandible 108 PE NA NA No Hemangiopericytoma
45 Woo (43) 42 F Mandible 108 PE 192 pg/mL (N: 1–71) 98 pg/mL (POD 11) Persistence Patient on oral phosphate solution with close follow-up last FGF-23 92 pg/mL PMTMCT
46 Savage (44) 73 F Left maxillary sinus 84 111In-pentetreotide NA NA No Hemangiopericytoma
47 Kurien (45) 55 M Right sphenoid, ethmoid sinus 24 CT NA NA No Hemangiopericytoma
48 Gupta (46) 51 M Nasal cavity 108 FDG-PET NA NA No PMTMCT
49 Gore (47) 52 F Nasal cavity 48 Octreoscan 573 Ru/mL (N <230) Normal (45 min post surgery) No PMTMCT
50 Kobayashi (48) 53 F Temporal bone 48 SVS 558.8 pg/mL (N: 4–54.3) Normal (POD 4) No PMTMCT
51 Shelekhova (49) 70 F Maxillary sinus NA MRI NA NA NA PMTMCT
52 Shelekhova (49) 53 M Frontal sinus NA CT NA NA NA PMTMCT
53 Pedrazzoli (50) 37 F Right maxillary sinus 32 CT NA NA No Hemangiopericytoma
54 Mori (51) 42 M Left maxillary alveolus 36 MRI 241 pg/mL (N: 10–50) Normal (1 h post surgery) No PMTMCT
55 Parshwanath (52) 42 F Left nasal cavity and ethmoid sinus 42 CT NA NA No PMT
56 Battoo (53) 34 F Left nasal cavity 60 PE NA NA NA Giant cell tumor
57 Peterson (54) 33 F Maxillary sinus NA NA NA NA NA PMT
58 Peters (55) 22 M Right temporal lobe mass 96 PE NA NA Persistence Three craniotomies with angioembolization, RT, PRRT, octreotide, dasatinib Hemangiopericytoma
59 Akhter (56) 52 M C5 vertebrae NA FDG-PET NA NA No PMTMCT
60 Xian-Ling (57) 43 F Right petrous apex 48 MRI NA NA Persistence Octreotide therapy
PMTMCT
61 Xian-Ling (57) 42 F Left ethmoid sinus 24 Octreoscan NA NA No PMTMCT
62 Guglielmi (58) 22 M Left ethmoid sinus 24 Octreoscan NA NA Persistence Repeat surgery
Hemangiopericytoma
63 Uno (59) 53 F Right temporal bone 48 CT >200 (N: 10–50 pg/mL) <50 (POD-2) NA PMT-MCT
64 Uno (59) 61 M Left basi frontalis 60 CT 400 (N: 10–50 pg/mL) <3 pg/mL (immediately) Persistence Repeat surgery
PMT-MCT
65 Andreupoulou (60) 63 M Left frontal lobe NA SVS 156 pg/mL 101 pg/mL (6 months post RT) At 6 months, patient had declining FGF-23 PMTMCT
66 Bergwitz (61) 56 M Mandible 228 PE 870 Ru/ml (N <180) NA Persistence Multiple surgeries, cinacalcet
Ameloblastic fibrosarcoma
67 Monappa (62) 35 M Right mandible 36 PE NA NA No PMTMCT
68 Chokyu (63) 57 M Middle cranial fossa 24 MRI 84 pg/mL (N: 10–50) 14 pg/mL (POD 7) No PMT
69 Chiam (64) 55 M Right nasal cavity 18 MRI 232 RU/mL (N <180) 18RU/mL (<180) day 5 No PMTMCT
70 Cho (65) 47 F Nasal cavity, ethmoidal sinus 36 CT NA NA No Hemangiopericytoma
72 Brandwein-Gensler (67) 66 F Nasal cavity, maxilla NA PE NA NA No Glomangiopericytoma
73 Munoz (68) 60 M Posterior neck 24 FDG-PET 575 RU/mL (N <180) Normal No PMTMCT
74 Chang (69) 37 m Left nasal cavity 60 PE NA NA No Hemangiopericytoma
75 Jiang (70) 38 F Mandible 24 Octreoscan NA NA No PMT-MCT
76 Jiang (70) 69 F Mandible 240 Octreoscan 393 pg/mL (N: 10–50) 8 No PMT-MCT
77 Jiang
(70)
28 M Mandible 48 Octreoscan NA NA No Odontogenic fibroma
78 Jiang (70) 56 F Mandible 120 Octreoscan NA NA No PMT-MCT
79 Jiang (70) 55 F Lower gingiva 204 Octreoscan NA NA No PMT-MCT
80 Jiang (70) 45 F Mandible 132 Octreoscan NA NA No Odontogenic fibroma
81 Jiang (70) 50 F Mandible 36 Octreoscan NA NA No PMT-MCT
82 Jiang (70) 27 M Maxilla 72 Octreoscan NA NA No Odontogenic fibroma
83 Jiang (70) 49 F Nasal sinus 72 Octreoscan NA NA Recurrence Observation PMT-MCT
84 Jiang (70) 24 M Nasal sinus 48 Octreoscan NA NA No PMT-MCT
85 Jiang (70) 45 F Nasal sinus 120 Octreoscan NA NA No PMT-MCT
86 Jiang (70) 57 F Nasal sinus 102 Octreoscan NA NA No PMT-MCT
87 Fatani (71) 58 M Floor of mouth, mandible 240 CT NA NA Recurrence Multiple surgeries, wedge lung resection Malignant PMTMCT
88 Mathis (72) 28 F Cribriform plate 36 MRI NA NA No PMTMCT
89 Mathis (72) 32 M Anterior cranial fossa, ethmoid sinus 12 CT NA NA Persistence Multiple surgeries
PMTMCT
90 Tarasova (73) 60 F Left frontal mass 48 SVS 132 pg/mL (N: 10–50) 134 Ru/mL (N <180) (3 years after RT) No NA
91 Papierska (74) 40 NA Right maxillary sinus NA Octreoscan 260.4 Ru/ml (N: 5-105) NA NA Glomangiopericytoma
92 Lee (75) 60 F Right maxillary sinus 72 CT NA NA No Glomangiopericytoma
93 Allevi (76) F Right maxillary sinus Octreoscan NA NA No PMT hemangiopericytoma
94 Annamalai (77) 49 M Left nasal cavity 180 FDG-PET/DOTA 224.5 RU/mL (N <150) 64.6 RU/mL (POD 2) No PMTMCT
95 Okamiya (78) 35 F Left ethmoid sinus 8 FDG-PET 147 pg/mL (N: 14–40) 16 pg/mL No PMTMCT
96 Arnaoutakis (54) 50 F Right ethmoid sinus 6 PE NA NA NA PMT
97 Mok (79) 48 M Right maxillary sinus 12 MRI NA NA No PMT
98 Fernández-Cooke (80) 3 M Maxilla and mandible 6 PE 395.1 pg/mL (N <40) 1267.2 RU/ML (N <60) Normal Persistence RFA, Local steroid infiltration, calcitonin, bisphosphonates, propranolol, cinacalcet Central giant cell granuloma
99 Fathalla (81) 49 F Right frontal lobe 36 Octreoscan 609 RU/mL (N: 0–180) NA No PMTMCT
100 Ray (82) 35 M Left nasal cavity 24 CT 5 X N NA No Hemangiopericytoma
101 Qari (83) 60 M Gingiva of mandibular teeth 72 PE NA NA No PMT
102 Wasserman (84) 50 M C3 vertebrae 24 NA NA NA No PMTMCT
103 Wasserman (84) 33 F Nose, lips, tongue 120 NA NA NA Persistence NA Malignant PMTMCT
104 Mani (85) 56 M Occipital bone 36 PE NA NA No PMTMCT
105 Yu (86) 37 M Maxilla 36 PE 129.97 pg/mL (N: 33.9–51.6) 64.9 pg/mL No PMTMCT
106 Yu (86) 50 M Mandible 6 PE 312.84 pg/mL (N: 33.9–51.6) NA No Spindle cell tumor with PMT features
107 Yu (86) 50 M Left nasal cavity 72 Octreoscan 272.71 pg/mL (N: 33.9–51.6) 5.93 pg/mL No PMTMCT
108 Yu (86) 38 F Left nasal cavity and ethmoid sinus 12 Octreoscan 350.9 pg/mL (N: 33.9–51.6) NA No PMTMCT
109 Takashi (87) 77 M Left parotid gland 96 FDG-PET 186.9 pg/mL 6.5 pg/mL No PMTMCT
110 Gresham (88) 42 M Ethmoid mass 36 MRI NA NA No Glomangioma
111 Agaimy (89) 48 M Nasal cavity NA NA NA NA Cellular, nondescript
112 Lee (90) 33 M Right mandible 156 Ga-DOTANOC 86.7 pg/mL (N: 10–50) NA No Giant cell granuloma
113 Lee (90) 52 M Left ethmoid sinus 6 Ga-DOTANOC 492.3 pg/mL (N: 10–50) NA Persistence RT PMT
114 Schober (91) 59 F Right fronto-basal region 22 SVS 1600 Ru/mL (N: 26–110) 74 Ru/mL Recurrence Repeat surgery
Meningioma
115 Zuo (92) NA M Left nasal cavity 36 Octreoscan NA NA No PMT
116 Zuo (92) NA F Left maxillary bone 36 FDG-PET NA NA No PMT
117 Hana (93) 38 M Bilateral ethmoid sinus 84 MRI 120 pg/mL (N: 10–50) ND (POD-1) Persistence Repeat surgery PMTMCT
118 Chanukya (94) 31 M Left nasal cavity 24 Ga-DOTANOC 1310 Ru/mL (N: 0–150) 109 Ru/mL (1 month post surgery) No Hemangiopericytoma
119 Gonzalez (95) 42 M Nasofrontal sinus 72 PE 75.9 pg/mL (N: 8–54) 8.4 pg/mL No PMTMCT
120 Singh (96) 67 M Posterior wall of mastoid antrum 204 Ga-DOTANOC 237 Ru/mL (N: 0–150) NA NA PMT
121 Singh (96) 45 M Left side of body of mandible 12 Ga-DOTANOC 1553 Ru/mL (N: 0–150) NA NA PMT
122 Pelletier (97) 37 M Mandible NA SVS f/b MRI 310 Ru/mL (N: 19–114) NA NA NA
123 Pelletier (97) 49 F Mandible Octreoscan of growing lesion on MRI with FDG-avidity and gradient on SVS 1194 Ru/mL (N: 19–114) 200 Ru/mL Persistence NA NA
125 Villepelet (99) 41 F Right ethmoid sinus NA CT NA 48 pg/mL (POD-5) No PMT
126 Pelo (100) 62 F Left TMJ 60 PE NA NA No PMT
127 He (101) 54 F Right parotid 24 Ga-DOTANOC NA NA NA Salivary basal cell adenoma
128 Wu (102) 49 F Right mandible 216 NA NA NA Persistence Multiple surgeries Odontogenic fibroma
129 Wu (102) 20 F Left maxilla 48 NA NA NA No Odontogenic fibroma
130 Wu (102) 30 F Right maxilla 60 NA NA NA No PMT of mixed epithelial & connective tissue type
131 Wu (102) 36 M Left mandible 60 NA NA NA No PMT of mixed epithelial & connective tissue type
132 Wu (102) 25 M Right maxilla 72 NA NA NA No PMT of mixed epithelial and connective tissue type
133 Wu (102) 15 F Right mandible 24 NA NA NA No PMT of mixed epithelial and connective tissue type
134 Wu (102) 41 M Right mandible 60 NA NA NA NA PMT of mixed epithelial and connective tissue type
135 Wu (102) 34 M Left maxilla 72 NA NA NA No PMT of mixed epithelial and connective tissue type
136 Wu (102) 50 M Right mandible 18 NA NA NA No PMT of mixed epithelial and connective tissue type
137 Wu (102) 66 M Right maxilla 108 NA NA NA No PMT of mixed epithelial and connective tissue type
138 Wu (102) 26 M Left maxilla 36 NA NA NA No PMT of mixed epithelial and connective tissue type
139 Wu (102) 32 M Right maxilla 36 NA NA NA No PMT of mixed epithelial and connective tissue type
140 Wu (102) 41 M Right mandible 60 NA NA NA No PMT of mixed epithelial and connective tissue type
141 Wu (102) 22 M Right mandible 24 NA NA NA No PMT of mixed epithelial and connective tissue type
142 Wu (102) 31 M Right maxilla 36 NA NA NA No PMT of mixed epithelial and connective tissue type
143 Wu (102) 51 M Left mandible 132 NA NA NA No PMT of mixed epithelial and connective tissue type
144 Wu (102) 75 M Right mandible 72 NA NA NA No PMT of mixed epithelial and connective tissue type
145 Ding (103) 66 F Right nasal cavity 48 Ga-DOTATATE NA NA NA NA
146 Ding (103) 41 M Right mandible 108 Ga-DOTATATE NA NA NA NA
147 Mishra (104) 46 M Right temporal lobe mass 60 Ga-DOTANOC 1028 Ru/mL (N <180) NA NA PMTMCT
148 Mishra (104) 52 F Left skull base tumor 24 Ga-DOTANOC 725 Ru/mL (N <180) 150 Ru/mL (3 months post-surgery) No PMTMCT
149 Li (105) 40 F Left nasal cavity 12 History NA NA Recurrence Repeat surgery twice Hemangiopericytoma
150 Acharya (106) 42 M Right mandible 12 FDG-PET 332 Ru/mL (N <180) 53 Ru/mL (POD 54) No PMTMCT
151 Kurien (107) 39 F Right nasal cavity 24 NA 260 Ru/mL (N <180) 40 Ru/mL No PMTMCT
152 Kurien (107) 36 F Left ethmoid sinus 24 NA NA 126 Ru/mL No PMTMCT
153 Kurien (107) 51 M Middle turbinate 36 NA 604 Ru/mL (N <180) <5 Ru/mL No PMTMCT
154 Kurien (107) 44 M Middle turbinate 48 NA 145 Ru/mL (N <180) 94.7 Ru/mL No PMTMCT
155 Kurien (107) 55 M Posterior ethmoid, sphenoid 24 NA NA NA No PMTMCT
156 Kurien (107) 37 F Anterior ethmoid with intracranial extension 36 NA 695 Ru/mL (N <180) 38 Ru/mL Persistence RT Malignant PMTMCT
157 Kurien (107) 62 F Nasal cavity, all PNS 48 NA NA 899 Ru/mL Persistence Observation PMTMCT
158 Paul (108) 54 F Left mandible 24 Ga-DOTATATE 1094 Ru/mL (N <180) 369 Ru/mL (POD-5) 44 Ru/mL (4 months post-surgery) No PMTMCT
159 Pal (109) 28 M Mandible NA Ga-DOTATATE 201 Ru/mL (N <180) 307 Ru/mL Persistent Medical management Hemangiopericytoma
160 Pal (109) 52 F Right nasal cavity NA Ga-DOTATATE 814 Ru/mL (N <180) NA No Arteriovenous hemangioma
161 Pal (109) 36 F Left maxillary sinus NA Ga-DOTATATE 1239 Ru/mL (N <180) NA No PMTMCT
162 Pal (109) 58 M Left nasal cavity NA Ga-DOTATATE 513 Ru/mL (N <180) NA No Hemangiopericytoma
163 Pal (109) 36 F Left nasal cavity NA FDG-PET 2467 Ru/mL (N <180) NA No Hemangiopericytoma

F, female; M, male; N, normal value; NA, not available; OF, ossifying fibroma like; PE, physical examination; PMTMCT, phosphaturic mesenchymal tumor mixed connective tissue type; POD, post-op day; PRRT, peptide receptor radionuclide therapy; RT, radiation therapy; SVS, selective venous sampling of FGF-23; UD, undetectable.