Thussu 2002.
| Methods | Randomised clinical trial. Single centre in India. Duration of trial 1.5‐3 years in two groups. |
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| Participants | People with seizures and CT scan suggestive of NCC Age range: 4 to 52 years, Mean ages in group A and B 19.5 ± ‐8.79 years and 25.6 ± 12.5 years, respectively. 53% of patients were males. Total: 73 people, 47 in group A treated with AEDs for 6 months, 26 in group B treated for 24 months. Follow‐up: every 2 months for 12 months after withdrawal of drugs. Exclusion criteria: people with persistent lesions requiring albendazole therapy. |
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| Interventions | AEDs for 6 months in group A, 24 months in group B. Group A 25 received carbamazepine, 22 received phenytoin. Group B 13 each received carbamazepine and phenytoin. Exact dosage and formulations not stated. Mentioned to have received quote: "therapeutic dosage according to weight". |
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| Outcomes | Seizure recurrence after withdrawal of AED. Correlation of seizure recurrence with CT Scan findings. |
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| Notes | ||
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Randomisation based on lottery system |
| Allocation concealment (selection bias) | Unclear risk | Not stated |
| Blinding of participants and personnel (performance bias) All outcomes | High risk | Not stated |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not stated |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Number of patients excluded or withdrawing from the study not mentioned |
| Selective reporting (reporting bias) | Unclear risk | Protocol not available. Insufficient information to confirm reporting bias. |
| Other bias | Unclear risk | Seizure recurrence discussed but timing of recurrence, i.e. during or after AED therapy not clear |