Table 1.

Comparison of information stored in binding interaction databases

Parameters	Binding MOAD	AffinDB	Ki DB	PDBbind	BindingDB	KDBI	KOFFI (This project)
Focus	PDB protein–ligand (small molecules, short peptides, oligo-nucleotides, cofactors) complexes	Protein–ligand complexes of the PDB	Drugs and drug candidates	Biomolecular complexes of the PDB	Drugs and drug candidates (including data from other databases, such as AffinDB)	All biomolecular interactions described in literature	All biomolecular interactions described in open-access literature
KD/KA	✔	✔	✕	✔	✔	✔	✔
kon & koff	✕	✕	✕	✕	✔	✔	✔
IC50	✔	✔	✕	✔	✔	✔	✕
KI	✔	✔	✔	✔	✔	✔	✕
ΔG	✕	✔	✕	✕	✔	✕	✕
PDB Subset	✔	✔	✕	✔	✔	✕	✕
Method	✕	✔	✕	✕	✔	✕	✔
Device	✕	✕	✕	✕	✔	✕	✔
Rating	✕	✕	✕	✕	✕	✕	✔
Manual curation	✔	✔	?	✔	✔	✔	✔