Table 2.
Relation of the continuous plasma FFAs levels and cardiovascular risk factors with MACEs
| Variables | Univariate Cox regression | Multivariate Cox regression | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age | 1.024 (1.016–1.032) | < 0.001 | 1.020 (1.010–1.029) | < 0.001 |
| Sex | 1.015 (0.849–1.213) | 0.870 | – | |
| BMI | 0.990 (0.965–1.016) | 0.457 | – | |
| LVEF | 0.975 (0.962–0.987) | < 0.001 | 0.979 (0.971–0.988) | < 0.001 |
| Hypertension | 1.320 (1.111–1.586) | 0.002 | 1.221 (1.017–1.466) | 0.032 |
| DM status | 1.352 (1.201–1.522) | 0.020 | 1.200 (1.060–1.359) | 0.004 |
| Smoke | 1.005 (0.857–1.179) | 0.951 | – | |
| FH | 1.240 (0.973–1.582) | 0.082 | ||
| Log transformed TG | 1.038 (1.980–1.100) | 0.205 | – | – |
| HDL-C | 1.142 (0.856–1.522) | 0.376 | – | |
| LDL-C | 1.014 (0.937–1.097) | 0.730 | – | |
| GS | 1.007 (1.005–1.009) | < 0.001 | 1.005 (1.003–1.007) | < 0.001 |
| Log2FFAs | 1.361 (1.191–1.554) | < 0.001 | 1.242 (1.084–1.424) | 0.002 |
| Baseline Statin | 0.817 (0.697–0.959) | 0.013 | 0.792 (0.671–0.936) | 0.006 |
Univariate and multivariate Cox proportional hazards regression analysis was performed to test statistical significance
MACEs were cardiovascular mortality, non-fatal myocardial infarction (MI), stroke and post-discharge unplanned revascularization
MACEs major cardiovascular adverse events, BMI body mass index, TG triglyceride, LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol, FFAs free fatty acids, LVEF left ventricular ejection fraction, DM diabetes mellitus, FH family history of coronary artery disease, GS gensini score