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. 2019 Sep 8;22(1):40–54. doi: 10.22074/cellj.2020.6550

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The Cell Journal (Yakhteh) is an open access journal which means the articles are freely available online for any individual author to download and use the providing address. The journal is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported License which allows the author(s) to hold the copyright without restrictions that is permitting unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

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Fig.2 — Effect of plasma-derived exosomes on the expression levels of microRNAs and mRNAs. The expression levels of A. hsa-miR-155-5p, B. hsa-let-7g-5p, C. SOCS-1 and D. INPP5D in the NK cells treated with IL-2/IL- 15 and plasma-derived exosome of patients with DLBCL compared to the untreated NK cells were determined in healthy donors, responsive DLBCL patients and refractory/relapsed DLBCL patients. NK cells were treated with 20 µg plasma-derived exosome of patients with DLBCL for 20 hours and they were then collected for preparation of total RNA. miRNAs (hsa- miR-155-5p and hsa-let-7g-5p) and RNA expression (SOCS-1 and INPP5D) were quantified by qRT-PCR. Degree of significance in treated NK cells with exosomes compared to the untreated NK cells was indicated by *P= 0.05, **P= 0.01 and ***P= 0.001 in each group. Each column shows mean of -..Ct ± standard error (SE). NK cells; Natural killer cells, IL; Interleukin, DLBCL; Diffuse large B-cell lymphoma, and qRT-PCR; Quantitative reverse transcription polymerase chain reaction.