Fig.5.
Effect of plasma-derived exosome of DLBCL patients on proliferation of labeled NK cell with CFSE. A. CFSE-positive NK cell population of a representative responsive DLBCL patient was cultured in the absence or presence of plasma-derived exosome from DLBCL patients, for three days. The dotted blue line represents unstained NK cells. Gray line with an empty profile in histograms indicates unstimulated CFSE-labeled NK cells and B. Degree of significance in the treated NK cells with plasma-derived exosomes of responsive or refractory/relapsed patients with DLBCL compared to the untreated NK cells, is indicated by *P=0.05, **P=0.01, and ***P=0.001 in each group. Each column illustrates the mean SE for proliferation rate of NK cells. DLBCL; Diffuse large B-cell lymphoma and NK; Natural killer cells.