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. 2019 Sep 8;22(1):40–54. doi: 10.22074/cellj.2020.6550

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The Cell Journal (Yakhteh) is an open access journal which means the articles are freely available online for any individual author to download and use the providing address. The journal is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported License which allows the author(s) to hold the copyright without restrictions that is permitting unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

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Fig.6 — Effect of plasma-derived exosome of DLBCL patients on the NK cell cytotoxicity. I. CFSE-stained K562 cells were co-cultured with NK cells at different E/T ratios. The CFSE-stained K562 cells were first gated by FSC and SSC characteristics. Both dot plots and histograms show that CFSE-stained K562 target cells were killed by NK cells treated with 20 μg plasma-exosomes of refractory/relapsed patients in A. Healthy donor and B. Responsive patient using E/T ratio of 2:1. The numbers in the panels denote percentage of 7-AAD positive cells. II. Variety of these killing activities were statistically analyzed at different E/T ratios, including A. 8:1, B. 4:1, C. 2:1, and D. 1:1 in the absence or presence of plasma-derived exosome of patients with DLBCL in healthy donors, responsive DLBCL patients and refractory/relapsed DLBCL patients. Degree of significance is highlighted by *P≤0.05 and **P≤0.01 in each group. Each point illustrates mean of the NK cell cytotoxicity percentage in each group. DLBCL; Diffuse large B-cell lymphoma and NK; Natural killer cells.