Table 2.

The severity of skin irAEs based on the Common Terminology Criteria for Adverse Events (CTCAE) [21]

Grade	Description
G1	Skin lesions cover < 10% of the body surface area with or without symptoms (e.g. itching, burning, etc.)
G2	Skin lesions cover 10–30% of the body surface area with or without symptoms (e.g. itching, burning, etc.), limited daily activities
G3	Skin lesions cover > 30% of the body surface area or G2 with significant clinical symptoms, limited self-care
G4	Epidermal detachment and necrosis, skin lesions cover > 30% of the body surface area, accompanying symptoms (erythema, purpura, epidermal detachment)