Table 1.
Compositions of polyvinyl alcohol and chitosan hydrogels with oxytetracycline hydrochloride.
| Formulations | Independent variables levels | |||
|---|---|---|---|---|
| X1 (mg) | X2 (% w/v) | X3 (% w/v) | X4 (n) | |
| F1 | 750 | 3.33 | 0.75 | 3 |
| F2 | 750 | 5 | 1 | 3 |
| F3 | 750 | 7.5 | 0.75 | 3 |
| F4 | 750 | 5 | 0.5 | 3 |
| F5 | 500 | 5 | 0.75 | 3 |
| F6 | 1000 | 5 | 0.75 | 3 |
| F7 | 750 | 7.5 | 0.5 | 5 |
| F8 | 750 | 3.33 | 0.5 | 5 |
| F9 | 750 | 7.5 | 1 | 5 |
| F10 | 500 | 3.33 | 0.75 | 5 |
| F11 | 1000 | 7.5 | 0.75 | 5 |
| F12 | 500 | 5 | 1 | 5 |
| F13 | 500 | 7.5 | 0.75 | 5 |
| F14 | 750 | 3.33 | 1 | 5 |
| F15 | 500 | 5 | 0.5 | 5 |
| F16 | 1000 | 3.33 | 0.75 | 5 |
| F17 | 1000 | 5 | 0.75 | 5 |
| F18 | 750 | 5 | 0.5 | 5 |
| F19 | 1000 | 3.33 | 0.75 | 7 |
| F20 | 750 | 5 | 0.75 | 5 |
| F21 | 750 | 5 | 1 | 7 |
| F22 | 500 | 5 | 0.75 | 7 |
| F23 | 750 | 5 | 0.5 | 7 |
| F24 | 1000 | 5 | 0.75 | 7 |
| F25 | 750 | 7.5 | 0.75 | 7 |
X1, drug amount; X2, amount of polyvinyl alcohol; X3, amount of chitosan; X4, freeze-thaw cycle.