Table 3.

Prognostic significance of clinicopathologic factors including SHMT2 was analyzed with univariate analysis.

Variables	5-year survival rate	P*
Sex
Female	28.6	0.333
Male	33.3
Age
<60	25	0.577
≥60	34.9
Tumor size(cm)
≤5	51	0.001
>5	19
Histopathological grade
I	48.5	0.001
II	29.3
III	6.7
T stage
T1	83.3	0.001
T2	53.8
T3	29.4
T4	15.4
Lymphatic invasion
Negative	46.9	0.018
Positive	27.6
Distant metastasis
Negative	34.2	<0.001
Positive	0
TNM stage
I	60	<0.001
II	45.9
III	24.7
IV	0
SHMT2
Low	49.2	<0.001
High	15.9

SHMT2 is the abbreviation of serine hydroxymethyltransferase 2.

^*Calculated by log-rank test.