Table 1.
Clinical characteristics of histoplasmosis-induced HLH patients at our institution (n = 5).
| Case # | Year | Age | Gender | Race | Comorbid conditions | Immunosuppressive agent | Yeast in BM | Urine histoplasma Ag | Sites growing histoplasma | CXR findings |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2011 | 48 | M | White | HIV/CD4 count 50 | None | Yes | Above LoQ | Blood | No infiltrates |
| 2 | 2014 | 48 | F | White | MCTD | HCQ/prednisone 10 mg daily | No | Above LoQ | Blood | LAD without infiltrates |
| 3 | 2016 | 75 | M | White | Crohn's | Infliximab/azathioprine/prednisone | Yes | N/A (serum Ag: above LoQ) | Blood and BM | No infiltrates |
| 4 | 2017 | 46 | M | African American | Sarcoid | Prednisone | Yes | Above LoQ | Blood and BM | Diffuse infiltrate |
| 5 | 2017 | 41 | M | White | HIV/CD4 count 10 | None | N/A | Above LoQ | Blood | Diffuse infiltrate |
M: male; F: female; HIV: human immunodeficiency virus; MCTD: mixed connective tissue disease; N/A: not applicable, BM: bone marrow; dexa: dexamethasone; CXR: chest X-ray; Ag: antigen; LAD: lymphadenopathy; LoQ: limit of quantification; HCQ: hydroxychloroquine.