Table 1.

Diverse cell types mediate malaria-induced immune response and injury.

Cell type	Location	Function
Kupffer cell	Liver	(i) Phagocytosis of infected RBCs (ii) Recruitment of other immune cells by secretion of cytokines (iii) Prevention of parasitic infection in hepatocytes (iv) Limiting infection through induction of apoptosis
Splenic macrophages	Spleen	(i) Secretion of cytokines
Circulating monocytes	Blood	(ii) Phagocytosis of infected RBCs
Microglia	CNS	(i) Induce accumulation of perivascular macrophages (ii) Secretion of cytokines
Hofbauer cells (fetal)	Placenta	(i) Phagocytosis of infected RBCs (ii) Secretion of cytokines (iii) Interaction between maternal/fetal immunity
Intervillous monocytes (maternal)
Decidual macrophages (maternal)

Description of immune cells involved in malaria response by location/origin and function. CNS, central nervous system; RBC, red blood cell.