Table 3.

Reactions with the centrality score above the specified level of significance.

Reaction ID	Reaction name	EC number	Biological process	Centrality score	Reference
HBDG_c	Hemoglobin digestion		Cysteine and methionine	0.521053
T_c_to_a_C00073	L-Methionine transport reaction		Cysteine and methionine	0.442105
R00896_c	L-Cysteine:2-oxoglutarate aminotransferase	2.6.1.1	Cysteine and methionine	0.426316
T_c_to_r_C00641	1,2-Diacyl-sn-glycerol transport reaction		Glycerolipid	0.409357
R02251_r	Acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase	2.3.1.20	Glycerolipid pathway	0.324619
T_c_to_r_C00641	1,2-Diacyl-sn-glycerol transport reaction		Glycerophospholipid pathway	0.42986
R00177_c	ATP:L-methionine S-adenosyltransferase	2.5.1.6	Glycerophospholipid pathway	0.264179	Oyelade et al. [12]
R02037_R06868 _R06869_c	S-Adenosyl-L-methionine:(methyl)ethanolamine-phosphate N-methyltransferase	2.1.1.103	Glycerophospholipid pathway	0.255603	Choubey et al. [40], Pessi et al. [41], Witola et al. [42]
R00497_c	Gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)	6.3.2.3	Glycine, serine and threonine	0.287619	Chiappino-Pepe et al. [18], Huthmacher et al. [39]
R01061_c	D-Glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)	1.2.1.12 1.2.1.59	Glycolysis pathway	0.552381
R01068_c	D-Fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)	4.1.2.13	Glycolysis pathway	0.495238	Wanidworanun et al. [43]
R00769_c	UTP:D-fructose-6-phosphate 1-phosphotransferase	2.7.1.11	Glycolysis pathway	0.490476
R03427_c	Inositol-1,4-bisphosphate 1-phosphatase	3.1.3.57	Inositol phosphate pathway	0.533333
R04372_c	Phosphatidylinositol-3,4-bisphosphate 4-phosphatase	3.1.3.66	Inositol phosphate pathway	0.533333
R01187_c	1D-Myo-inositol 3-phosphate phosphohydrolase	3.1.3.25	Inositol phosphate pathway	0.47619
R01802_c	CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase	2.7.8.11	Inositol phosphate pathway	0.419048	Chiappino-Pepe et al. [18], Fatumo et al. [44]
R03429_c	Inositol-1,3,4-trisphosphate 5/6-kinase	2.7.1.159	Inositol phosphate pathway	0.285714
R01641_c	Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase	2.2.1.1	Pentose phosphate pathway	0.328478
R00720_c	Inosine 5′-triphosphate pyrophosphohydrolase	3.6.1.8 3.6.1.19	Purine metabolism	0.448718
R01231_c	Xanthosine-5′-phosphate:L-glutamine amido-ligase (AMP-forming)	6.3.5.2	Purine metabolism	0.37833	McConkey [46]
R00576_c	Glutamine-pyruvate transaminase	2.6.1.15	Purine metabolism	0.345098
R02024_c	2′-Deoxycytidine diphosphate:oxidized-thioredoxin 2′-oxidoreductase	1.17.4.1	Purine metabolism	0.340121	Barker et al. [47], Chakrabarti et al. [48], Lytton et al. [49]
R01135_c	IMP:L-aspartate ligase (GDP-forming)	6.3.4.4	Purine metabolism	0.330982	Eaazhisai et al. [50]
R00328_c	GDP phosphohydrolase	3.6.1.5; 3.6.1.6; 3.6.1.42	Purine metabolism	0.287731
R00570_c	ATP:CDP phosphotransferase	2.7.4.6	Pyrimidine	0.45977	Oyelade et al. [12], Chiappino-Pepe et al. [18]
R02024_c	2′-Deoxycytidine diphosphate:oxidized-thioredoxin 2′-oxidoreductase	1.17.4.1	Pyrimidine	0.419157	Barker et al. [47], Chakrabarti et al. [48], Chiappino-Pepe et al. [18], Lytton et al. [49]
R00571_c	UTP:ammonia ligase (ADP-forming)	6.3.4.2	Pyrimidine	0.255172	Chiappino-Pepe et al. [18]
R00573_c	UTP:L-glutamine amido-ligase (ADP-forming)	6.3.4.2	Pyrimidine	0.255172	Chiappino-Pepe et al. [18]
R06517_c	Acyl-CoA:sphingosine N-acyltransferase	2.3.1.24	Sphingolipid	0.431917	Gerold and Schwarz [32]
R02251_c	Acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase	2.3.1.20	Sphingolipid	0.325708
R00351_m	Acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysis)	2.3.3.1 2.3.3.3	TCA	0.377739
R02569_m	Acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase	2.3.1.12	TCA	0.281995	Chiappino-Pepe et al. [18]