Table 3.
Univariate and multivariate analyses of DFS in the entire patients (n = 427).
| Clinicopathological parameters | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (years) (≤65/>65) | 1.078 (0.757–1.536) | 0.676 | ||
| Gender (male/female) | 0.685 (0.448–1.047) | 0.080 | ||
| Cirrhosis (yes/no) | 1.596 (1.017–2.506) | 0.042 | 1.708 (1.079–2.703) | 0.022 |
| Virus hepatitis (HBV/HCV/non-HBV, non-HCV) | 0.954 (0.834–1.091) | 0.489 | ||
| Child-Pugh (A/B) | 6.454 (3.366–12.374) | <0.001 | 6.373 (3.289–12.349) | <0.001 |
| ALT (U/L) (≤60/>60) | 1.237 (0.886–1.726) | 0.212 | ||
| T-Bil (Umol/L) (≤20/>20) | 0.973 (0.678–1.397) | 0.884 | ||
| CA125 (U/mL) (≤30/>30) | 1.913 (1.241–2.950) | 0.003 | ||
| Anatomical resection (yes/no) | 0.788 (0.591–1.050) | 0.104 | ||
| Surgical margin (mm) (≤10/>10) | 0.706 (0.472–1.056) | 0.090 | ||
| MTD (cm) (≤5/>5) | 2.085 (1.574–2.763) | <0.001 | 1.891 (1.379–2.592) | <0.001 |
| Number of nodules (1/>1) | 2.092 (1.509–2.899) | <0.001 | ||
| Microvascular invasion (yes/no) | 1.536 (1.122–2.102) | 0.007 | ||
| Differentiation (well/mod, poor) | 1.175 (0.769–1.796) | 0.455 | ||
| TNM stage∗(I/II/III) | 1.808 (1.504–2.147) | <0.001 | 1.358 (1.052–1.753) | 0.019 |
HBV, viral hepatitis B; HCV, viral hepatitis C; ALT, alanine transaminase; T-Bil, total bilirubin; MTD, maximal tumor diameter; IQR, interquartile range. ∗TNM stages were assigned according to the criteria described in the AJCC Cancer Staging Manual (8th Edition).