Table 4.
Univariate and multivariate analyses of OS in the entire patients (n = 427).
| Clinicopathological parameters | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (years) (≤65/>65) | 1.034 (0.655–1.632) | 0.887 | ||
| Gender (male/female) | 0.865 (0.513–1.458) | 0.586 | ||
| Cirrhosis (yes/no) | 2.313 (1.313–4.732) | 0.022 | 2.615 (1.266–5.401) | 0.009 |
| Virus hepatitis (HBV/HCV/non-HBV, non-HCV) | 1.036 (0.877–1.224) | 0.679 | ||
| Child-Pugh (A/B) | 5.782 (3.013–11.099) | <0.001 | 4.942 (2.395–10.198) | <0.001 |
| ALT (U/L) (≤60/>60) | 1.562 (1.050–2.323) | 0.028 | ||
| T-Bil (Umol/L) (≤20/>20) | 0.687 (0.413–1.142) | 0.147 | ||
| CA125 (U/mL) (≤30/>30) | 2.266 (1.361–3.771) | 0.002 | ||
| Anatomical resection (yes/no) | 0.746 (0.513–1.086) | 0.127 | ||
| Surgical margin (mm) (≤10/>10) | 0.498 (0.275–0.901) | 0.021 | ||
| MTD (cm) (≤5/>5) | 3.013 (2.140–4.243) | <0.001 | 2.709 (1.848–3.972) | <0.001 |
| Number of nodules (1/>1) | 2.064 (1.381–3.087) | <0.001 | ||
| Microvascular invasion (yes/no) | 1.583 (1.063–2.358) | 0.024 | ||
| Differentiation (well/mod, poor) | 1.357 (0.766–2.404) | 0.296 | ||
| TNM stage∗ (I/II/III) | 2.175 (1.745–2.712) | <0.001 | 1.471 (1.109–1.951) | 0.007 |
HBV: viral hepatitis B; HCV, viral hepatitis C; ALT, alanine transaminase; T-Bil, total bilirubin; MTD, maximal tumor diameter; IQR, interquartile range. ∗TNM stages were assigned according to the criteria described in the AJCC Cancer Staging Manual (8th Edition).