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. 2019 Sep 29;2019:2160642. doi: 10.1155/2019/2160642

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Copyright © 2019 Yuqing Wang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

SOD2-siRNA reversed curcumin-induced reduction of intracellular ROS and mitochondrial superoxide in HT22 cells exposed to OGD/R. The cells were divided into 5 groups, including control, OGD/R, Cur + OGD/R, SOD2-siRNA + Cur + OGD/R, and SC-siRNA + Cur + OGD/R; after 3 h OGD and 24 h reoxygenation, intracellular ROS and mitochondrial superoxide were evaluated. (a) Intracellular ROS fluorescence staining results. (b) SOD2-siRNA reversed curcumin-induced intracellular ROS reduction (n = 8). (c) SOD2-siRNA reversed curcumin-induced mitochondrial superoxide reduction (n = 8). (d) Mitochondrial superoxide fluorescence staining results. Results are expressed as means ± SD. ^∗P < 0.05; NS: no significance; Bar = 20 μm.