Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 20;294(41):15095–15103. doi: 10.1074/jbc.RA119.008491

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Hoang et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

Figure 3. — ANG depends on Nrf2 to induce ARE-dependent gene expression. A and B, in astrocytes, ANG-mediated hPAP activation (A) and induction of the expression of antioxidant genes (B) were comparable with those in Figs. 1A and 2A. These activities were absent in Nrf2-deprived astrocytes (Nrf2^−/−). Treating cells with heparin prior to ANG stimulation likewise prevented ANG-induced changes in hPAP activity (A). Significant changes in gene-expression level compared to Nrf2^−/− astrocytes are marked by asterisks, where * refers to p ≤ 0.05 and ** refers to p ≤ 0.01.