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. 2019 Oct 11;7:e7870. doi: 10.7717/peerj.7870

Figure 3. C. albicans provides S. gordonii antibiotic tolerance in biofilm co-cultures.

Figure 3

(A) Schematic of biofilm culture conditions, antibiotic treatment and measurement of biofilm weight following dessication. (B) Dry weight measurement (Mean ± SD) of S. gordonii and C. albicans biofilms with and without ampicillin at 24 h time point. There was no significant difference between dry weights of biofilms with and without ampicillin when C. albicans was present. However, significantly reduced biofilm dry weight was observed for single species S. gordonii biofilms with ampicillin. Statistical analysis was done by Student’s t-Test (p < 0.05). (C) Dry weight measurement (Mean ± SD) of S. gordonii and C. albicans biofilms with and without erythromycin at 24 h time point. There was no significant difference between dry weights of biofilms with and without erythromycin when C. albicans was present. However, significantly reduced biofilm dry weight was observed for single species S. gordonii biofilms with erythromycin. Three replicates were used for each experimental group and a minimum of two repeats were performed for each experiment. Statistical analysis was done using Student’s t-Test (p < 0.05).