Panel A. Poses of agonists 1, 7, and 8 relative to the surface of the FPR1 binding site. Key sub-areas of the FPR1 binding site are indicated with arrows and include two channels (A and C), two cavities (B and E), and the bottom (D), as described previously [82]. Surface coloring was made according to electrostatic properties, whereby negatively and positively charged areas are shown in red and blue, respectively. Panel B. Docking poses of benzimidazoles 7 (purple) and 8 (green) in FPR1. H-bonds are indicated with dashed lines.