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. Author manuscript; available in PMC: 2019 Oct 14.
Published in final edited form as: Curr Med Chem. 2014;21(13):1478–1504. doi: 10.2174/0929867321666131218095521

Table 10.

Agonist Activity of 2-(N-piperazinyl)acetamides 54-61 [79]

graphic file with name nihms-1052684-t0031.jpg
# R1 R2 R3 R4 EC50 (μM)a
FPR1 FPR2 PMN
54 H H F H N.A. 19.3 10.5
55 H Cl H H N.A. 15.1 16.4
56 H H H H N.A. 8.7 2.3
57 H H Cl H N.A. 2.1 2.0
58 H Cl CH3 H N.A. 4.3 1.0
59 CH3 Cl H H N.A. 4.1 1.8
60 CH3 H H Cl N.A. 9.4 0.4
61 H OCH3 H H N.A. 11.0 7.9
a

EC50 values were determined by measurement of Ca2+ flux in FPR1- and FPR2-transfected RBL cells or in human polymorphonuclear neutrophils (PMN). N.A., no activity observed.