Table 6.
# | R | EC50 (μM)a | ||
---|---|---|---|---|
FPR1 | FPR2 | PMN | ||
30 | Cl | N.A. | 0.4 | 0.7 |
31 | H | N.A. | 3.0 | 4.8 |
32 | F | N.A. | 0.9 | 1.2 |
33 | Br | N.A. | 0.1 | 1.2 |
EC50 values were determined by measurement of Ca2+ flux in FPR1- and FPR2-transfected HL-60 cells or in human polymorphonuclear neutrophils (PMN). N.A., no activity observed.