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. Author manuscript; available in PMC: 2019 Oct 14.

Published in final edited form as: Curr Med Chem. 2014;21(13):1478–1504. doi: 10.2174/0929867321666131218095521

Table 7.

Agonist Activity of Chiral N-phenylurea Derivatives 34-38 [80]


#	R	EC₅₀ (μM)^a
#	R	FPR1	FPR2	FPR3	PMN
34		4.5	0.14	11.5	3.2
35		1.8	0.04	6.5	1.2
36		0.3	0.004	0.1	0.7
37		0.08	0.007	0.5	0.5
38		N.A.	0.16	N.A.	4.4

^a

EC₅₀ values were determined by measurement of Ca²⁺ flux in FPR1-, FPR2-, and FPR3-transfected

HL-60 cells or in human polymorphonuclear neutrophils (PMN). N.A., no activity observed.